Cross-Reactivity

For cross-reactivity, my friend and I had five points in our notes.  We took each one and made a picture to help us remember.  Enjoy!

Honestly, reading the text or your notes first will make this much more helpful and relevant!  This does not go into detail on how these things work, these are just symbols for triggering recall.

 

Similar antigenic determinants

Pretty sneaky.  Viruses and bacteria getting in on the fun by looking similar to the normal host cells.

 

Vaccines

This one's kind of cool.  If two viruses have epitopes that react the same, then you could create a vaccine for one virus that would also give an immune response if exposed to the other virus.  The cow and the dotted stick person came from the example of cowpox and smallpox.

 

Tolerance

If you've studied social psych, you will be familiar with the in-group, out-group concept.  Our body doesn't (or shouldn't) attack our own blood cells, but we can develop antibodies to other types of blood through...cross-reactivity with similar antigens on microbes in our gut...you look up the rest.

 

Polysaccharide antigens

Yes, I had to look up a picture of a car in order to draw that.  If you want to know specifically what car I was attempting to draw please contact me :P  Okay, so here we have the key word "polysaccharide".  To us, this meant fashion Polly with a purse (sack) in a ride.  And we imagined cross-reactivity between the air and the hair, since the car is going one way and her hair is being blown quite the opposite way.

 

Antibody-antigen interactions

Guys, you may not be able to relate to this, but if you are a girl and you happen to have a little sister...let's just say I sometimes resort to initialling the tags on my clothing!  Sometimes antibodies can react with antigens they weren't meant for.  Just like in this picture, the little sister decides that since she can borrow her sister's clothes, she can also steal from her sister's friend's closet.

 

Reference:

Kindt, T., Goldsby, R., & Osborne, B. (2007). Kuby Immunology (6th ed., Chapter 6). New York: W. H. Freeman and Company.

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